Synthesis and antifungal activity of 2-heterocyclic- benzimidazole derivatives

Thirteen 2-heterocyclic-benzimidazole derivatives were synthesized from methyl ketone,diethyl oxalate or dimethyl oxalate,hydroxylamine hydrochloride,hydrazine hydrate as starting materials via several reactions including condensation,cyclization and hydrolysis.The structures of all compounds were confirmed by IR,ESI-MS and 1H NMR.Preliminary bioassay showed that all the compounds exhibit some fungicidal activity against six fungi tested at the concentration of 100 mg/L,among them,the inhibition rate of 2a-2d against Glomerella cingulata were above 80%, 4a showed 100% inhibition rate against Alternaria solani,G.cingulata and Magnaport hegrisease.