Study on the synthesis of the carbohydrate conjugates of fipronil and their phloem mobility in Ricinus communis

In order to further improve the phloem mobility of fipronil,six novel fipronil glucosides were synthesized by conjugation of fipronil with glucose,galactose and xylose.The phloem concentration of compounds(a-f) in Ricinus communis Linn.was determined by HPLC.Results showed that compounds(d,e,f) had good phloem mobility,the concentrations of d,e,f collected in third hour were 21.45,14.14 and 14.82 μ mol/L,respectively.The bioassays of fipronil and compounds(a-f) against Ostrinia furnacalis were conducted.Compared with fipronil(LC50 value was 4.49 μ mol/L),compounds(a-f) showed lower insecticidal activity against Ostrinia furnacalis (LC50 value between 47.54-78.00 μ mol/L).