Synthesis and fungicidal activity of 3-substituted-phenyl-4- acyloxy-2(1H)-quinolinones

Fifteen new quinolinone derivatives (5a-5o)were synthesized using 5-methyl anthranilic acid and anthranilic acid as raw materials by esterification,acylation,cyclization and then esterification.Their structures were confirmed by IR,ESI-MS and 1H NMR.Preliminary bioassay showed that the compound 5c exhibited good inhibiting effect against six tested fungi at the concentration of 100 mg/L,and the inhibition rate ranged from 61.7% to 92.9%;the compound 5i showed 96.1% inhibition rate against Fusarium oxysporum f.sp.Vasinfectum at the same concentration,and the inhibition rate was similar to azoxystrobin.