Study on synthesis and antifungal activity of 1-methyl-3- difluoromethyl pyrazolamide derivatives

Fourteen novel pyrazol-4-amide derivatives were synthesized from 3-difluoromethyl-1-methyl-1 H-pyrazole-4-carboxylic acid by the reaction of 3-difluoromethyl-1-methyl-1 H-pyrazole-4-carbonyl chloride with various amines.The structures of these compounds were confirmed by 1H NMR,MS,and IR.Antifungal activity test indicated that all of the synthesized compounds (6a-6g,7a-7g) showed different inhibition on tested plant pathogenic fungi at the concentration of 100 mg/L.The compounds 7a-7g exhibited good antifungal activity,and the growth inhibition rate of compounds 7a,7d,7g against Glomerella cingulata was above 90%.