Study on influence of veegum and the coordination of veegum with xanthan gum to physical stability of phoxim 300 capsule suspension
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Graphical Abstract
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Abstract
Rheology was used to study the influence of veegum and the coordination of veegum with xanthan gum (XG) to the physical stability of phoxim 300 CS.The results showed that,firstly,the use of veegum could obviously improve the physical stability.On the dosage of veegum was 2%,the system showed obvious thixotropism and the separation ratios at normal temperature(60 d) and 54 ℃ heat storage (14 d) decreased from 68.13% and 70.68% to 3.75% and 5.31%,respectively.Secondly,comparing with that using veegum alone,the coordination action of veegum with XG was more obvious,0.5% veegum and 0.3% XG using together could apparently improve the physical stability of the system.And the thixotropy increased with the increase of veegum dosage.The results indicated that veegum alone and the coordination of veegum with XG could apparently improve the physical stability of CS formulation.
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