Synthesis and antifungal activity of novel N-4-tert-butyl-6-aryl-5-(1,2,4-triazol-1-yl)-1,3-thiazin-2-yl amides

15 Novel compounds were synthesized from α-triazole pinacolone by condensation reaction,cyclization reaction and amidation reaction.Their structures were confirmed by IR,1H NMR and MS.The preliminary bioassay showed that all of the synthesized compounds have different inhibition on six tested plant pathogenic fungi at the concentration of 50 mg/L.The inhibition rates of compound 3a-3,3a-4,3a-5,3b-2 and 3b-3 against Botrytis cinerea were up to 80%. 3a-4 and 3a-5 were 78.6% and 82.4% against Fusarium oxysporum vasinfectum respectively.