Synthesis and fungicidal activity of 1-(3-chloropyridin-2-yl)-5-difluoromethyl-1H-pyrazole-4-carboxamide derivatives

1-(3-chloropyridin-2-yl)-5-difluoromethyl-1H-pyrazole-4-carbonyl chloride (6) was synthesized using 2,3-dichloropyridine(1) as raw materials by hydrazinolysis,cyclization,hydrolysis,acyl chlorination.Then 13 novel title compounds were synthesized by acylation of (6) with substituted anilines(7).The structures of the compounds were confirmed by LC-MS,1H NMR and elemental analysis.The preliminary biological activity showed that all the compounds exhibit mild inhibiting effect against all the tested strains at the concentration of 50 mg/L.Among them,the inhibitory rate of compound ZJ-10 against Botrytis cinerea was 76.03% at the concentration of 50 mg/L.